Tyro3 (D38C6) Rabbit mAb
货号：
5585S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 5585S |
| 反应种属 | Human/Mouse/Rat/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W/IP |
| 目标/特异性 | Tyro3 (D38C6) Rabbit mAb detects endogeneous levels of total Tyro3 protein. |
| 使用方法 | WB(1:1000)
IP (1:50) |
性能| 供应商 | CST |
| 背景 | Tyro3 is a receptor tyrosine kinase belonging to the TAM subfamily (Tyro3, Axl and Mer). All three members have similar domain structure composed of an extracellular region with 2 Ig-like domains, followed by 2 FNII-like domains, a single transmembrane region, and a cytoplasmic tyrosine kinase domain (1). The natural ligand for Tyro3, as well as Axl and Mer, is Gas6 (growth arrest-specific gene 6) (1,2). Expression pattern and target knockout data indicate an important role of Tyro3 in apoptotic cell phagocytosis of dendritic cells and macrophages (3), NK cell differentiation (4), reproductive neuron survival and migration (5), osteoclast stimulation (6,7), as well as cortical and hippocampal neuron function (8). Both MAPK and PI3K pathways have been suggested as downstream targets of Tyro3 activation (7,8). Tyro3 has also been shown to be correlated to melanoma tumorgenesis, likely through its reglulatory role in the expression of ongogenic microphthalmia-associated transcription factor (MITF) (9). |
| 存放说明 | -20C |
| 计算分子量 | 110, 130 |
参考图片Western blot analysis of extracts from COS-7 cells, and tissues from human and mouse brain using Tyro3 (D38C6) Rabbit mAb.用Tyro3 (D38C6) Rabbit mAb 对COS-7细胞的提取物以及人和小鼠的脑组织进行免疫印迹检测。 |
