| 货号 | 82723T |
| 同种亚型 | Rabbit IgG |
| 反应种属 | Human, |
| 来源宿主 | Rabbit IgG |
| 应用 | WB, IHC-P |
| 目标/特异性 | PD-L2 (D7U8C™) XP® Rabbit mAb recognizes endogenous levels of total PD-L2 protein. |
| 使用方法 | WB(1:1000) IHC-P (1:200) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | Programmed cell death 1 ligand 2 (PD-L2, B7-DC, CD273) is a member of the B7 family of cell surface ligands that regulate T-cell activation and immune responses (1,2). PD-L2 binds the PD-1 transmembrane receptor and inhibits T-cell activation. PD-L2 was discovered following a search for novel B7 protein homologs and was later shown to be expressed by activated dendritic cells, macrophages, and T-cells (1,3). Similar in structure to related B7 family members, PD-L2 protein contains extracellular IgV and IgC2 domains, a transmembrane domain, and a short, cytoplasmic region. Research studies demonstrate that PD-L2 is expressed in several tumor types, including lung cancer, renal cell carcinoma, melanoma, Hodgkins lymphoma and primary mediastinal large B-cell lymphoma (4-7). |
| 存放说明 | -20C |
| 计算分子量 | 45-60 |
| 参考文献 | 1 . Latchman, Y. et al. (2001) Nat Immunol 2, 261-8. 2 . Tseng, S.Y. et al. (2001) J Exp Med 193, 839-46. 3 . Messal, N. et al. (2011) Mol Immunol 48, 2214-9. 4 . Kim, M.Y. et al. (2015) Lung Cancer 88, 24-33. 5 . Taube, J.M. et al. (2014) Clin Cancer Res 20, 5064-74. 6 . Green, M.R. et al. (2010) Blood 116, 3268-77. 7 . Ansell, S.M. et al. (2015) N Engl J Med 372, 311-9. |
Immunohistochemical analysis of paraffin-embedded HDLM-2 (left) and PC-3 (right) cell pellets on SignalSlide® PD-L1 IHC Controls #13747 using PD-L2 (D7U8C) XP® Rabbit mAb. | |
Immunohistochemical analysis of paraffin-embedded human mediastinal large B-cell lymphoma using PD-L2 (D7U8C) XP® Rabbit mAb. | |
Immunohistochemical analysis of paraffin-embedded human colon carcinoma using PD-L2 (D7U8C) XP® Rabbit mAb. | |
Immunohistochemical analysis of paraffin-embedded human tonsil using PD-L2 (D7U8C) XP® Rabbit mAb. | |
Western blot analysis of HDLM-2 and Jurkat cell extracts using PD-L2 (D7U8C) XP® Rabbit mAb (upper) and β-Actin (D6A8) Rabbit mAb #8457 (lower). |
