Phospho-IRF-3 (Ser396) (D6O1M) Rabbit mAb (Alexa Fluor® 647 Conjugate)
货号：
10327T 基本售价：
1780.0 元 规格：
-
产品信息
概述| 货号 | 10327T |
| 同种亚型 | Rabbit IgG |
| 反应种属 | Human, Mouse, Rat |
| 应用 | F |
| 目标/特异性 | Phospho-IRF-3 (Ser396) (D6O1M) Rabbit mAb (Alexa Fluor® 647 Conjugate) recognizes endogenous levels of IRF-3 protein only when phosphorylated at Ser396. |
| 使用方法 | Flow Cytometry (1:50)
|
性能| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | Interferon regulatory factors (IRFs) comprise a family of transcription factors that function within the Jak/Stat pathway to regulate interferon (IFN) and IFN-inducible gene expression in response to viral infection (1). IRFs play an important role in pathogen defense, autoimmunity, lymphocyte development, cell growth, and susceptibility to transformation. The IRF family includes nine members: IRF-1, IRF-2, IRF-9/ISGF3γ, IRF-3, IRF-4 (Pip/LSIRF/ICSAT), IRF-5, IRF-6, IRF-7, and IRF-8/ICSBP. All IRF proteins share homology in their amino-terminal DNA-binding domains. IRF family members regulate transcription through interactions with proteins that share similar DNA-binding motifs, such as IFN-stimulated response elements (ISRE), IFN consensus sequences (ICS), and IFN regulatory elements (IRF-E) (2). |
| 存放说明 | 4C |
| 参考文献 | 1 . Taniguchi, T. et al. (2001) Annu Rev Immunol 19, 623-55.
2 . Honda, K. and Taniguchi, T. (2006) Nat Rev Immunol 6, 644-58.
|
参考图片Flow Cytometric analysis of HT-29 cells, untransfected (blue) or transfected with Poly (I:C) (green) using Phospho-IRF-3 (Ser396) (D601M) Rabbit mAb (Alexa Fluor® 647 Conjugate). |
