| 货号 | 4757T |
| 同种亚型 | Rabbit |
| 反应种属 | Human, |
| 来源宿主 | Rabbit |
| 应用 | WB |
| 目标/特异性 | Phospho-HER4/ErbB4 (Tyr1284) (21A9) Rabbit mAb detects endogenous levels of HER4/ErbB4 protein only when phosphorylated on Tyr1284. This antibody does not cross-react with other ErbB family members. |
| 使用方法 | WB(1:1000) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | The HER/ErbB receptor tyrosine kinase family has been implicated in normal development, cardiac function and cancer (1,2). HER4/ErbB4, like other family members, has four ectodomains, a single transmembrane domain and a cytoplasmic tail containing the active tyrosine kinase domain (3). By binding to neuregulins and/or EGF family ligands, ErbB4 forms either a homodimer or heterodimer with other ErbB family members, which results in receptor activation and signaling (3). ErbB4 is ubiquitously expressed with the highest expression occurring in brain and heart. The expression of ErbB4 in breast cancer, pediatric brain cancer and other types of carcinomas has been reported suggesting that ErbB4 expression is involved in both normal tissue development and carcinogenesis (3). |
| 存放说明 | -20C |
| 计算分子量 | 180 |
| 参考文献 | 1 . Holbro, T. and Hynes, N.E. (2004) Annu Rev Pharmacol Toxicol 44, 195-217. 2 . Roskoski, R. (2004) Biochem Biophys Res Commun 319, 1-11. 3 . Carpenter, G. (2003) Exp Cell Res 284, 66-77. |
Western blot analysis of extracts from various cell lines expressing different activated protein tyrosine kinases, using Phospho-HER4/ErbB4 (Tyr1284) (21A9) Rabbit mAb or Phospho-Tyrosine Mouse mAb (P-Tyr-100) #9411 (lower).Western blot法检测各种表达不同激活酪氨酸激酶的细胞的提取物，使用抗体为：Phospho-HER4/ErbB4 (Tyr1284) (21A9) Rabbit mAb （上）或Phospho-Tyrosine Mouse mAb (P-Tyr-100) #9411(下)。 |
