Phospho-Jak3 (Tyr980/981) (D44E3) Rabbit mAb
货号：
5031T 基本售价：
1600.0 元 规格：
-
产品信息
概述| 货号 | 5031T |
| 同种亚型 | Rabbit IgG |
| 反应种属 | Human,Mouse, |
| 来源宿主 | Rabbit IgG |
| 应用 | WB |
| 目标/特异性 | Phospho-Jak3 (Tyr980/981) (D44E3) Rabbit mAb detects endogenous levels of Jak3 when phosphorylated at Tyr980/981. Some reactivity may exist with single phosphorylation at these sites. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | Members of the Janus family of tyrosine kinases (Jak1, Jak2, Jak3 and Tyk2) are activated by ligands binding to a number of associated cytokine receptors (1). Upon cytokine receptor activation, Jak proteins become autophosphorylated and phosphorylate their associated receptors to provide multiple binding sites for signaling proteins. These associated signaling proteins, such as Stats (2), Shc (3), insulin receptor substrates (4) and focal adhesion kinase (FAK) (5), typically contain SH2 or other phospho-tyrosine-binding domains. |
| 存放说明 | -20C |
| 计算分子量 | 115 |
| 参考文献 | 1 . Leonard, W.J. and OShea, J.J. (1998) Annu Rev Immunol 16, 293-322.
2 . Darnell, J.E. (1997) Science 277, 1630-5.
3 . VanderKuur, J. et al. (1995) J Biol Chem 270, 7587-93.
4 . Argetsinger, L.S. et al. (1995) J Biol Chem 270, 14685-92.
5 . Zhu, T. et al. (1998) J Biol Chem 273, 10682-9.
6 . Thomis, D.C. et al. (1995) Science 270, 794-7.
7 . Rikova, K. et al. (2007) Cell 131, 1190-203.
8 . Nosaka, T. et al. (1995) Science 270, 800-2.
9 . Park, S.Y. et al. (1995) Immunity 3, 771-82.
10 . Russell, S.M. et al. (1994) Science 266, 1042-5.
11 . Johnston, J.A. et al. (1994) Nature 370, 151-3.
12 . Oakes, S.A. et al. (1996) Immunity 5, 605-15.
13 . Zhou, Y.J. et al. (1997) Proc Natl Acad Sci USA 94, 13850-5.
14 . Cheng, H. et al. (2008) Mol Cell Biol 28, 2271-82.
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参考图片Western blot analysis of extracts from NK-92 cells, untreated or treated with Human Interleukin-2 (hIL-2) #8907 (10 ng/ml, 15 minutes), using Phospho-Jak3 (Tyr980/981) (D44E3) Rabbit mAb (upper) or Jak3 Antibody #3775 (lower).Western免疫印迹。用Phospho-Jak3 (Tyr980/981) (D44E3) Rabbit mAb (上图) 或 Jak3 Antibody #3775 (下图)研究未经处理的和经(hIL-2) #8907 (10 ng/ml, 15 min)处理的NK-92 细胞的细胞提取液。 |
