Lck (D88) XP® Rabbit mAb【科瑞奥博】

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Lck (D88) XP® Rabbit mAb

货号： 2984T 基本售价： 1550.0 元规格： -

产品信息

概述
货号	2984T
同种亚型	Rabbit IgG
反应种属	Human,
来源宿主	Rabbit IgG
应用	WB, IHC-P
目标/特异性	Lck (D88) XP® Rabbit mAb detects endogenous levels of total Lck protein. This antibody does not cross-react with other Src family members.
使用方法	WB(1:1000) IHC-P (1:200)

性能
供应商	CST
灵敏度	Endogenous
背景	Lck belongs to the Src-like non-receptor tyrosine kinase family with the typical Src family kinase structure: a unique amino terminal domain (Src homology 4 domain, SH4) followed by an SH3 domain, an SH2 domain, a kinase domain (SH1), and a carboxy-terminal negative regulatory domain (1). Lck activity is controlled by the interactions of SH2 and SH3 domains as well as tyrosine phosphorylation status of the activation loop (2,3). Lck is recruited to the T cell receptor (TCR) complex upon stimulation and activates downstream tyrosine kinases to initiate T cell signaling (4). Lck is also found to be involved in the regulation of mitochondrial apoptosis pathways and may be responsible for some anticancer drug induced apoptosis (5,6).
存放说明	-20C
计算分子量	56
参考文献	1 . Palacios, E.H. and Weiss, A. (2004) Oncogene 23, 7990-8000. 2 . Mustelin, T. and Taskén, K. (2003) Biochem J 371, 15-27. 3 . Gervais, F.G. et al. (1993) Mol Cell Biol 13, 7112-21. 4 . Straus, D.B. and Weiss, A. (1992) Cell 70, 585-93. 5 . Belka, C. et al. (2003) Oncogene 22, 176-85. 6 . Gruber, C. et al. (2004) Biochem Pharmacol 67, 1859-72.

参考图片

Immunohistochemical analysis of paraffin-embedded human lung carcinoma using Lck (D88) XP® Rabbit mAb.免疫组织化学染色分析石蜡包埋人肺癌组织。所用抗体为Lck (D88) XP® Rabbit mAb。

Immunohistochemical analysis of paraffin-embedded Colo205 (positive) (left) and HeLa (negative) (right) cell pellets using Lck (D88) XP® Rabbit mAb.免疫组织化学染色分析石蜡包埋Colo205 (阳性) (左图) 和 HeLa (阴性) (右图)细胞沉淀。所用抗体为Lck (D88) XP® Rabbit mAb。

Immunohistochemical analysis of paraffin-embedded human lymphoma using Lck (D88) XP® Rabbit mAb.免疫组织化学染色分析石蜡包埋人淋巴瘤组织。所用抗体为Lck (D88) XP® Rabbit mAb。

Immunohistochemical analysis of paraffin-embedded human tonsil using Lck (D88) XP® Rabbit mAb.免疫组织化学染色分析石蜡包埋人扁桃体组织。所用抗体为Lck (D88) XP® Rabbit mAb。

Western blot analysis of extracts from Ramos and Jurkat cells using LcK (D88) XP® Rabbit mAb.Western免疫印迹。用LcK (D88) XP® Rabbit mAb研究Ramos和Jurkat 细胞的细胞提取液。