Prostate Specific Membrane Antigen (D7I8E) XP® Rabbit mAb【科瑞奥博】

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Prostate Specific Membrane Antigen (D7I8E) XP® Rabbit mAb

货号： 12815T 基本售价： 1550.0 元规格： 20ul

产品信息

概述
货号	12815T
同种亚型	Rabbit IgG
反应种属	Human/Mouse/Rat
来源宿主	Rabbit
应用	W/IHC-P
目标/特异性	Prostate Specific Membrane Antigen (D7I8E) XP^® Rabbit mAb recognizes endogenous levels of total prostate specific membrane antigen. An SDS resistant dimer at approximately 200 kDa can be detected depending on sample preparation conditions.
使用方法	WB(1:1000) IHC-P (1:100)

性能
供应商	CST
灵敏度	Endogenous
背景	Prostate specific membrane antigen (PSMA, also known as FOLH1), a type II transmembrane protein of the M28 family, has both folate hydrolase and N-acetylated-alpha-linked acidic dipeptidase activity. PSMA was originally identified in the LNCaP cell line, which was derived from a prostate adenocarcinoma lymph node metastasis (1,2). PSMA is an established prostate cancer marker (3); however, it is expressed in other tissues, including kidney, liver, and urinary bladder (4), and it is associated with tumor neovasculature (5) as well. Research studies suggest that PSMA is both a potential diagnostic readout and therapeutic target (6-8).
存放说明	-20C
计算分子量	100
参考文献	1 . Horoszewicz, J.S. et al. (1987) Anticancer Res 7, 927-35. 2 . Israeli, R.S. et al. (1993) Cancer Res 53, 227-30. 3 . Ben Jemaa, A. et al. (2010) J Exp Clin Cancer Res 29, 171. 4 . Kinoshita, Y. et al. (2006) World J Surg 30, 628-36. 5 . Chang, S.S. et al. (1999) Mol Urol 3, 313-320. 6 . Mease, R.C. et al. (2013) Curr Top Med Chem 13, 951-62. 7 . Frigerio, B. et al. (2013) Eur J Cancer 49, 2223-32. 8 . Denmeade, S.R. et al. (2012) Sci Transl Med 4, 140ra86.

参考图片

Immunohistochemical analysis of paraffin-embedded human prostate adenocarcinoma using Prostate Specific Membrane Antigen (D7I8E) XP^® Rabbit mAb.

Immunohistochemical analysis of paraffin-embedded human ovarian serous adenocarcinoma using Prostate Specific Membrane Antigen (D7I8E) XP^® Rabbit mAb. Note positive staining of blood vessels.

Immunohistochemical analysis of paraffin-embedded human prostate adenocarcinoma using Prostate Specific Membrane Antigen (D7I8E) XP^® Rabbit mAb in the presence of control peptide (left) or antigen-specific peptide (right).

Western blot analysis of extracts from various cell lines using Prostate Specific Membrane Antigen (D7I8E) XP^® Rabbit mAb (upper) or β-Actin (D6A8) Rabbit mAb #8457 (lower).