| 货号 | 5583T |
| 同种亚型 | Rabbit IgG |
| 反应种属 | Human,Mouse,Rat,Monkey, |
| 来源宿主 | Rabbit IgG |
| 应用 | WB, IP , IHC-P , IF-IC |
| 目标/特异性 | DDR1 (D1G6) XP® Rabbit mAb detects endogeneous levels of total DDR1 protein. |
| 使用方法 | WB(1:1000) IP (1:100) IHC-P (1:6400) IF-IC (1:800) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | The discoidin domain receptors (DDRs) are receptor tyrosine kinases with a discoidin homology repeat in their extracellular domains, activated by binding to extracellular matrix collagens. So far, two mammalian DDRs have been identified: DDR1 and DDR2 (1). They are widely expressed in human tissues and may have roles in smooth muscle cell-mediated collagen remodeling (2). Aberrant expression and signaling of DDRs have been implicated in human disease related to increased matrix degradation and remodeling, such as cardiovascular disease, liver fibrosis, and tumor invasion (1). |
| 存放说明 | -20C |
| 计算分子量 | 125 |
| 参考文献 | 1 . Vogel, W. (1999) FASEB J 13 Suppl, S77-82. 2 . Ferri, N. et al. (2004) Am J Pathol 164, 1575-85. |
Immunohistochemical analysis of paraffin-embedded human colon carcinoma using DDR1 (D1G6) XP (TM) RmAb.用抗DDR1的兔源单克隆抗体(D1G6) XP®对石蜡包埋的人结肠癌组织进行免疫组化检测。 | |
Immunohistochemical analysis of paraffin-embedded human lung carcinoma using DDR1 (D1G6) XP (TM) RmAb in the presence of control peptide (left) or antigen-specific peptide (right).在对照多肽（左）和抗原特异多肽（右）存在的情况下用抗DDR1的兔源单克隆抗体(D1G6) XP®对石蜡包埋的人结肠癌组织进行免疫组化检测。 | |
Western blot analysis of extracts from MCF7 and C6 cell lines, and tissue from mouse brain using DDR1 (D1G6) XP® Rabbit mAb.用抗DDR1的兔源单克隆抗体(D1G6) XP®对MCF7 和 C6细胞的提取物进行免疫印迹检测。 | |
Confocal immunofluorescent analysis of MCF7 cells (left) and HeLa cells (right) using DDR1 (D1G6) XP® Rabbit mAb (green). Actin filaments were labeled with DY-554 phalloidin (red). Blue pseudocolor = DRAQ5® #4084 (fluorescent DNA dye).用抗DDR1的兔源单克隆抗体(D1G6) XP®（绿色）对MCF7细胞（左）和HeLa细胞（右）进行免疫共聚焦检测。肌动蛋白微丝用DY-554 phalloidin (红色)标记。蓝色 = DRAQ5® #4084进行的DNA染色 |
