| 货号 | 2475T |
| 同种亚型 | Rabbit IgG |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W/IHC-P |
| 目标/特异性 | PSA/KLK3 (D11E1) XP® Rabbit mAb recognizes endogenous levels of total PSA/KLK3 protein. |
| 使用方法 | WB(1:1000) IHC-P (1:1000) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | Kallikrein 3 (KLK3), also known as Prostate Specific Antigen (PSA), is a member of the glandular kallikrein subfamily of serine proteases (1). It is produced by prostate epithelial cells and is secreted into prostatic ducts. Upon cleavage of 7 N-terminal amino acids (2), it is activated to liquefy semen in the seminal coagulum. Although PSA/KLK3 is produced in healthy individuals, investigators have found abnormally high levels in the blood of men with advanced prostate cancer (3,4). |
| 存放说明 | -20C |
| 计算分子量 | 29 |
| 参考文献 | 1 . Watt, K.W. et al. (1986) Proc Natl Acad Sci U S A 83, 3166-70. 2 . Balk, S.P. et al. (2003) J Clin Oncol 21, 383-91. 3 . Thompson, I.M. et al. (2004) N Engl J Med 350, 2239-46. |
Western blot analysis of extracts from human sperm and LNCaP and DU 145 cells using PSA/KLK3 (D11E1) XP® Rabbit mAb. DU 145 cells are negative as expected.Western blot检测人血清和 LNCaP、DU 145细胞提取物，采用PSA/KLK3 (D11E1) XP® Rabbit mAb。DU 145细胞同预期一致，结果为阴性。 | |
Immunohistochemical analysis of paraffin-embedded cell pellets, LNCaP (left) or DU 145 (right), using PSA/KLK3 (D11E1) XP® Rabbit mAb.免疫组化分析石蜡包埋细胞颗粒，LNCaP (左图)或DU 145 (右图)，采用的抗体是PSA/KLK3 (D11E1) XP® Rabbit mAb。 | |
Immunohistochemical analysis of paraffin-embedded human prostate adenocarcinoma using PSA/KLK3 (D11E1) XP® Rabbit mAb in the presence of control peptide (left) or antigen-specific peptide (right).在对照多肽(左图)或者抗原特异性多肽(右图)存在的情况下，免疫组化分析石蜡包埋人前列腺癌样本，采用的抗体是PSA/KLK3 (D11E1) XP® Rabbit mAb。 |
