| 货号 | 79322T |
| 同种亚型 | Rabbit IgG |
| 反应种属 | H M |
| 来源宿主 | Rabbit IgG |
| 应用 | W IF-F |
| 目标/特异性 | SORL1 (D8D4G) Rabbit mAb recognizes endogenous levels of total SORL1 protein. |
| 使用方法 | WB(1:1000) IF-F (1:800) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | SORL1, also called SorLA, is a 250 kDa type-1 membrane protein found in neurons of the central and peripheral nervous system (1). SORL1 is related to the yeast transporter Vps10p (2). While its exact function is unknown, because it shuttles between the Golgi apparatus and endolysosomal compartments, and given its structural similarity with Vps10p, it has been suggested that SORL1 acts in intracellular trafficking (3). Interestingly, SORL1 expression has been shown to be decreased in the brain of patients with Alzheimers disease (4), and research studies have demonstrated a role for SORL1 as a neuronal sorting receptor that binds APP and regulates its trafficking and proteolytic processing, thus regulating the production of amyloid-beta peptides (5). |
| 运输条件 | 0.75 |
| 存放说明 | -20C |
| 计算分子量 | 250 |
| 参考文献 | 1 . Yamazaki, H. et al. (1996) J Biol Chem 271, 24761-8. 2 . Marcusson, E.G. et al. (1994) Cell 77, 579-86. 3 . Jacobsen, L. et al. (2002) FEBS Lett 511, 155-8. 4 . Scherzer, C.R. et al. (2004) Arch Neurol 61, 1200-5. 5 . Andersen, O.M. et al. (2005) Proc Natl Acad Sci U S A 102, 13461-6. |
Confocal immunofluorescent analysis of mouse hippocampus (left), cortex (middle), or cerebellum (right) using SORL1 (D8D4G) Rabbit mAb (green). Blue pseudocolor = DRAQ5® #4084 (fluorescent DNA dye). | |
Western blot analysis of extracts from various tissues using SORL1 (D8D4G) Rabbit mAb (upper) and β-Actin (D6A8) Rabbit mAb #8457 (lower). |
