| 货号 | 3504T |
| 同种亚型 | Rabbit |
| 反应种属 | Human,Mouse,Rat,Monkey, |
| 来源宿主 | Rabbit IgG |
| 应用 | WB, IP |
| 目标/特异性 | TBK1/NAK (D1B4) Rabbit mAb detects endogenous levels of total TBK1/NAK protein. |
| 使用方法 | WB(1:1000) IP (1:100) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | TBK1 (TANK-binding kinase 1)/NAK (NF-κB activating kinase) is an IκB kinase (IKK)-activating kinase and can activate IKK through direct phosphorylation (1). TBK1 was identified through association with the TRAF binding protein, TANK, and found to function upstream of NIK and IKK in the activation of NF-κB (2). TBK1/NAK induces IκB degradation and NF-κB activity through IKKβ. NAK may mediate IKK and NF-κB activation in response to growth factors that stimulate PKCε activity (1). TBK1 plays a pivotal role in the activation of IRF3 in the innate immune response (3). |
| 存放说明 | -20C |
| 计算分子量 | 84 |
| 参考文献 | 1 . Tojima, Y. et al. (2000) Nature 404, 778-82. 2 . Pomerantz, J.L. and Baltimore, D. (1999) EMBO J 18, 6694-704. 3 . Fitzgerald, K.A. et al. (2003) Nat Immunol 4, 491-6. |
Western blot analysis of extracts from various cell lines using TBK1/NAK (D1B4) Rabbit mAb.Western免疫印迹。用TBK1/NAK (D1B4) Rabbit mAb研究各种细胞的细胞提取液。 |
