| 货号 | 2883T |
| 同种亚型 | Rabbit |
| 反应种属 | Human/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | TCF3 (D15G11) Rabbit mAb detects endogenous levels of total TCF3 protein. |
| 使用方法 | WB(1:1000) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | LEF1 and TCF are members of the high mobility group (HMG) DNA binding protein family of transcription factors that consists of the following: Lymphoid Enhancer Factor 1 (LEF1), T Cell Factor 1 (TCF1), TCF3, and TCF4 (1). LEF1 and TCF1 were originally identified as important factors regulating early lymphoid development (2) and act downstream in Wnt signaling. LEF1 and TCF bind to Wnt response elements to provide docking sites for β-catenin, which translocates to the nucleus to promote the transcription of target genes upon activation of Wnt signaling (3). LEF1 and TCF are dynamically expressed during development and aberrant activation of the Wnt signaling pathway is involved in many types of cancers including colon cancer (4,5). |
| 存放说明 | -20C |
| 计算分子量 | 78 |
| 参考文献 | 1 . Waterman, M.L. (2004) Cancer Metastasis Rev 23, 41-52. 2 . Schilham, M.W. and Clevers, H. (1998) Semin Immunol 10, 127-32. 3 . Brantjes, H. et al. (2002) Biol Chem 383, 255-61. 4 . Reya, T. and Clevers, H. (2005) Nature 434, 843-50. 5 . Logan, C.Y. and Nusse, R. (2004) Annu Rev Cell Dev Biol 20, 781-810. 6 . Merrill, B.J. et al. (2001) Genes Dev. 15, 1688-1705. 7 . Nguyen, H. et al. (2006) Cell 127, 171-183. 8 . Cole, M.F. et al. (2008) Genes Dev. 22, 746-755. |
Western blot analysis of total lysates from various cell lines using TCF3 (D15G11) Rabbit mAb. 使用TCF3 (D15G11) Rabbit mAb兔单抗对多种全细胞提取物进行western blot分析。 |
