| 货号 | 3736T |
| 同种亚型 | Rabbit IgG |
| 反应种属 | Human, |
| 来源宿主 | Rabbit IgG |
| 应用 | WB, IP |
| 目标/特异性 | TNF-R1 (C25C1) Rabbit mAb detects endogenous levels of human TNF-R1 protein. This antibody does not appear to cross-react with other related family members. |
| 使用方法 | WB(1:1000) IP (1:100) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | TNF-α is an important cytokine produced by numerous cell types including neutrophils, activated lymphoctyes, macrophages an NK cells. It plays a critical role in inflammatory responses and in apoptosis (1). TNF-α exists as a membrane-anchored and soluble form, both of which show biological activity. Response to TNF-α is mediated through two receptors, TNF-R1, which is widely expressed, and TNF-R2, which is expressed mainly in immune and endothelial cells (2). Antagonists to TNF-α have been validated as therapeutic targets for rheumatoid arthritis and other immune disorders (3). |
| 存放说明 | -20C |
| 计算分子量 | 55 |
| 参考文献 | 1 . Aggarwal, B.B. (2003) Nat Rev Immunol 3, 745-56. 2 . Locksley, R.M. et al. (2001) Cell 104, 487-501. 3 . Taylor, P.C. et al. (2004) Curr Opin Biotechnol 15, 557-63. 4 . Tartaglia, L.A. et al. (1991) Proc Natl Acad Sci U S A 88, 9292-6. 5 . Peschon, J.J. et al. (1998) J Immunol 160, 943-52. 6 . Tartaglia, L.A. et al. (1993) Cell 73, 213-6. 7 . Rothe, J. et al. (1993) Nature 364, 798-802. 8 . Chen, G. and Goeddel, D.V. (2002) Science 296, 1634-5. 9 . Humbert, M. et al. (1994) Am J Respir Crit Care Med 149, 1681-5. 10 . Schröder, J. et al. (1995) Infection 23, 143-8. |
Western blot analysis of extracts from A549, LN-18 and HeLa cells using TNF-R1 (C25C1) Rabbit mAb.Western免疫印迹。用TNF-R1 (C25C1) Rabbit mAb研究 A549, LN-18 和 HeLa 细胞的细胞提取液。 |
