| 货号 | 3879T |
| 同种亚型 | Rabbit |
| 反应种属 | Human,Mouse,Rat,Monkey, |
| 来源宿主 | Rabbit IgG |
| 应用 | WB, IP |
| 目标/特异性 | Snail (C15D3) Rabbit mAb detects endogenous levels of total Snail protein. |
| 使用方法 | WB(1:1000) IP (1:50) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | Snail is a zinc-finger transcription factor that can repress E-cadherin transcription. Downregulation of E-cadherin is associated with epithelial-mesenchymal transition during embryonic development, a process also exploited by invasive cancer cells (1-3). Indeed, loss of E-cadherin expression is correlated with the invasive properties of some tumors and there is a considerable inverse correlation between Snail and E-cadherin mRNA levels in epithelial tumor cell lines (4,5). In addition, Snail blocks the cell cycle and confers resistance to cell death (6). Phosphorylation of Snail by GSK-3 and PAK1 regulates its stability, cellular localization and function (7-10). |
| 存放说明 | -20C |
| 计算分子量 | 29 |
| 参考文献 | 1 . Barrallo-Gimeno, A. and Nieto, M.A. (2005) Development 132, 3151-61. 2 . Cano, A. et al. (2000) Nat. Cell Biol. 2, 76-83. 3 . Batlle, E. et al. (2000) Nat. Cell Biol. 2, 84-89. 4 . Yokoyama, K. et al. (2003) Int. J. Oncol. 22, 891-898. 5 . Yokoyama, K. et al. (2001) Oral Oncol. 37, 65-71. 6 . Vega, S. et al. (2004) Genes Dev. 18, 1131-1143. 7 . Zhou, B.P. et al. (2004) Nat. Cell Biol. 6, 931-940. 8 . Bachelder, R.E. et al. (2005) J. Cell Biol. 168, 29-33. 9 . Yook, J.I. et al. (2005) J. Biol. Chem. 280, 11740-11748. 10 . Yang, Z. et al. (2005) Cancer Res. 65, 3179-3184. |
Western blot analysis of extracts from various cell lines using Snail (C15D3) Rabbit mAb.使用Snail（C15D3）兔单抗对多种细胞提取物进行western blot分析。 |
