| 货号 | 13031T |
| 同种亚型 | Rabbit IgG |
| 反应种属 | Human/Mouse/Monkey |
| 来源宿主 | Rabbit |
| 应用 | IHC-P |
| 目标/特异性 | LKB1 (D60C5F10) Rabbit mAb (IHC Formulated) recognizes endogenous levels of total LKB1 protein. |
| 使用方法 | IHC-P(1:250) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | LKB1 (STK11) is a serine/threonine kinase and tumor suppressor that helps control cell structure, apoptosis and energy homeostasis through regulation of numerous downstream kinases (1,2). A cytosolic protein complex comprised of LKB1, putative kinase STRAD, and the MO25 scaffold protein, activates both AMP-activated protein kinase (AMPK) and several AMPK-related kinases (3). AMPK plays a predominant role as the master regulator of cellular energy homeostasis, controlling downstream effectors that regulate cell growth and apoptosis in response to cellular ATP concentrations (4). LKB1 appears to be phosphorylated in cells at several sites, including human LKB1 at Ser31/325/428 and Thr189/336/363 (5). |
| 存放说明 | -20C |
| 参考文献 | 1 . Baas, A.F. et al. (2004) Trends Cell Biol 14, 312-9. 2 . Marignani, P.A. (2005) J Clin Pathol 58, 15-9. 3 . Lizcano, J.M. et al. (2004) EMBO J 23, 833-43. 4 . Hardie, D.G. (2004) J Cell Sci 117, 5479-87. 5 . Sapkota, G.P. et al. (2002) Biochem J 362, 481-90. 6 . Jenne, D.E. et al. (1998) Nat Genet 18, 38-43. 7 . Sanchez-Cespedes, M. (2007) Oncogene 26, 7825-32. |
Immunohistochemical analysis of paraffin-embedded human prostate carcinoma using LKB1 (D60C5F10) Rabbit mAb (IHC Formulated). 使用LKB1 (D60C5F10) Rabbit mAb 兔单抗(IHC Formulated)对石蜡包埋的人前列腺癌组织进行免疫组化分析。 | |
Immunohistochemical analysis of paraffin-embedded human ovarian carcinoma using LKB1 (D60C5F10) Rabbit mAb (IHC Formulated). 使用LKB1 (D60C5F10) Rabbit mAb兔单抗 (IHC Formulated)对石蜡包埋的卵巢癌组织进行免疫组化分析。 | |
Immunohistochemical analysis of paraffin-embedded cell pellets, LKB1 positive COS-7 (left) and LKB1 negative A549 (right), using LKB1 (D60C5F10) Rabbit mAb (IHC-Formulated). 使用LKB1 (D60C5F10) Rabbit mAb兔单抗 (IHC Formulated)对石蜡包埋的细胞，LKB1阳性的COS-7(左)和LKB1阴性A549(右)进行免疫组化分析。 | |
Immunohistochemical analysis of paraffin-embedded human lung carcinoma using LKB1 (D60C5F10) Rabbit mAb (IHC Formulated). 使用LKB1 (D60C5F10) Rabbit mAb兔单抗 (IHC Formulated)对石蜡包埋的人肺癌组织进行免疫组化分析。 |
