Keratin 8/18 (C51) Mouse mAb【科瑞奥博】

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Keratin 8/18 (C51) Mouse mAb

货号： 4546T 基本售价： 1350.0 元规格： -

产品信息

概述
货号	4546T
同种亚型	Mouse IgG1
反应种属	Human,Monkey,
来源宿主	Mouse IgG1
应用	WB, IHC-P , F , IF-IC
目标/特异性	Keratin 8/18 (C51) Mouse mAb detects endogenous levels of total keratins 8 and 18. The antibody does not cross-react with other keratins.
使用方法	WB(1:1000) IHC-P (1:25) F (1:50) IF-IC (1:100)

性能
供应商	CST
灵敏度	Endogenous
背景	Keratins (cytokeratins) are intermediate filament proteins that are mainly expressed in epithelial cells. Keratin heterodimers composed of an acidic keratin (or type I keratin, keratins 9 to 23) and a basic keratin (or type II keratin, keratins 1 to 8) assemble to form filaments (1,2). Keratin isoforms demonstrate tissue- and differentiation-specific profiles that make them useful as biomarkers (1). Mutations in keratin genes are associated with skin disorders, liver and pancreatic diseases, and inflammatory intestinal diseases (3-6).
存放说明	-20C
计算分子量	46 Keratin 18. 55 Keratin 8.
参考文献	1 . Moll, R. et al. (1982) Cell 31, 11-24. 2 . Chang, L. and Goldman, R.D. (2004) Nat Rev Mol Cell Biol 5, 601-13. 3 . Ramaekers, F.C. and Bosman, F.T. (2004) J Pathol 204, 351-4. 4 . Lane, E.B. and McLean, W.H. (2004) J Pathol 204, 355-66. 5 . Zatloukal, K. et al. (2004) J Pathol 204, 367-76. 6 . Owens, D.W. and Lane, E.B. (2004) J Pathol 204, 377-85.

参考图片

Confocal immunofluorescent analysis of HeLa cells using Keratin 8/18 (C51) Mouse mAb (green). Red = Propidium Iodide (PI)/RNase Staining Solution #4087.

Western blot analysis of extracts from various cell lines, using Keratin 8/18 (C51) Mouse mAb.使用Keratin 8/18 (C51) Mouse mAb，免疫印迹（Western Blot）分析不同细胞中Keratin 8/18蛋白水平。

Immunohistochemical analysis of paraffin-embedded H358 xenograft, using Keratin 8/18 (C51) Mouse mAb.使用Keratin 8/18 (C51) Mouse mAb，免疫组化分析H358 xenograft石蜡切片。

Immunohistochemical analysis of paraffin-embedded human prostate carcinoma, using Keratin 8/18 (C51) Mouse mAb.使用Keratin 8/18 (C51) Mouse mAb，免疫组化分析人源前列腺癌组织石蜡切片。

Immunohistochemical analysis of paraffin-embedded human squamous cell carcinoma of the lung, using Keratin 8/18 (C51) Mouse mAb.使用Keratin 8/18 (C51) Mouse mAb，免疫组化分析人源肺鳞状细胞癌组织石蜡切片。

Immunohistochemical analysis of paraffin-embedded human colon carcinoma, using Keratin 8/18 (C51) Mouse mAb.使用Keratin 8/18 (C51) Mouse mAb，免疫组化分析人源结肠癌组织石蜡切片。

Immunohistochemical analysis of paraffin-embedded human breast carcinoma, using Keratin 8/18 (C51) Mouse mAb.使用Keratin 8/18 (C51) Mouse mAb，免疫组化分析人源乳腺癌组织石蜡切片。

Flow cytometric analysis of MCF-7 cells, using Keratin 8/18 (C51) Mouse mAb (blue) compared to a nonspecific negative control antibody (red).与非特异阴性control antibody (红色)比较，使用Keratin 8/18 (C51) Mouse mAb (蓝色)标记，流式细胞仪分析MCF-7细胞。