| 货号 | 4655T |
| 同种亚型 | Rabbit IgG |
| 反应种属 | Human, |
| 来源宿主 | Rabbit IgG |
| 应用 | WB, IP |
| 目标/特异性 | TESK1 (D49D4) Rabbit mAb detects endogenous levels of total TESK1 protein. |
| 使用方法 | WB(1:1000) IP (1:200) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | Testis-specific kinase 1 (TESK1) is a LIMK-related protein kinase originally identified to be expressed highly in testes and subsequently shown to be expressed in a wide variety of tissues and cell types (1-4). TESK1 phosphorylates the actin severing protein cofilin at Ser3, inactivating cofilin and thus regulating the organization of the actin cytoskeleton (2). Integrin signaling activates TESK1 activity and leads to stress fiber formation and cell spreading (2,5,6). TESK1 is involved in regulation of ERK signaling through its interaction with Spry2 (7) and regulation of cell spreading through its interaction with the focal adhesion protein actopaxin/α-parvin (5). |
| 存放说明 | -20C |
| 计算分子量 | 68 |
| 参考文献 | 1 . Toshima, J. et al. (1995) J Biol Chem 270, 31331-7. 2 . Toshima, J. et al. (2001) Mol Biol Cell 12, 1131-45. 3 . Toshima, J. et al. (2001) J Biol Chem 276, 31449-58. 4 . Toshima, J. et al. (2001) Biochem Biophys Res Commun 286, 566-73. 5 . LaLonde, D.P. et al. (2005) J Biol Chem 280, 21680-8. 6 . Tsumura, Y. et al. (2005) Biochem J 387, 627-37. 7 . Chandramouli, S. et al. (2008) J Biol Chem 283, 1679-91. |
Western blot analysis of extracts from various cell types using TESK1 (D49D4) Rabbit mAb. 使用TESK1 (D49D4) Rabbit mAb兔单抗，免疫印迹（Western Blot）分析不同细胞中TESK1蛋白水平。 |
