| 货号 | 5665T |
| 同种亚型 | Rabbit IgG |
| 反应种属 | Human,Mouse,Rat,Hamster,Monkey, |
| 来源宿主 | Rabbit IgG |
| 应用 | WB |
| 目标/特异性 | Nicastrin (D38F9) Rabbit mAb recognizes endogenous levels of total Nicastrin protein. |
| 使用方法 | WB(1:1000) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | Nicastrin is a transmembrane glycoprotein serving as an essential component of the γ-secretase complex (1,2). Nicastrin is physically associated with presenilin and plays an important role in the stabilization and correct localization of presenilin to the membrane-bound γ-secretase complex (3). Nicastrin also serves as a docking site for γ-secretase substrates such as APP and Notch, directly binding to them and properly presenting them to γ-secretase to ensure the correct cleavage process (2,4). |
| 存放说明 | -20C |
| 计算分子量 | 110, 120 |
| 参考文献 | 1 . Yu, G. et al. (2000) Nature 407, 48-54. 2 . Esler, W. P. et al. (2002) Proc. Natl. Acad. Sci. USA 99, 2720-2725. 3 . Kopan, R. and Goate, A. (2002) Neuron 33, 321-324. 4 . Chen, F. et al. (2001) Nat. Cell Biol. 3, 751-754. |
Western blot analysis of extracts from various cell lines using Nicastrin (D38F9) Rabbit mAb. Western blot分析多个细胞系提取物，使用的抗体是Nicastrin (D38F9) Rabbit mAb 兔单抗。 |
