| 货号 | 5689T |
| 同种亚型 | Mouse IgG1 |
| 反应种属 | Human,Mouse,Rat,Monkey, |
| 来源宿主 | Mouse IgG1 |
| 应用 | WB, IP |
| 目标/特异性 | PPP2R2A (2G9) Mouse mAb recognizes endogenous levels of total PPP2R2A/PP2A, B55-α/PR55-α protein. This antibody cross-reacts with overexpressed PPP2R4 and PPP2R5D proteins. |
| 使用方法 | WB(1:1000) IP (1:50) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | Protein phosphatase 2A subunit B isoform R2-α (PPP2R2A) is the component of regulatory subunit B of serine/threonine protein phosphatase 2A (PP2A). PPP2R2A belongs to the R2/B55/PR55 family of regulatory subunit B (1). Evidence suggests that subunit PPP2R2A enhances TGF-β, Activin, and Nodal signaling pathways (7) and may play an important role in cell cycle regulation (2-4). PPP2R2A/PP2A, B55-α/PR55-α isoform interacts with the type I TGF-β receptors via unique WD-40 repeats (5) that contribute to the anti-proliferative function of TGF-β receptors (6).蛋白磷酸酶2A亚基B的异构体R2-α (PPP2R2A)是丝氨酸/苏氨酸蛋白磷酸酶2A(PP2A)的调节亚基B的组成部分。PPP2R2A属于调节亚基B的R2/B55/PR55家族(1)。有证据表明亚基PPP2R2A能够增强TGF-β、激活素和Nodal信号通路(7)并在细胞周期调节中发挥重要作用(2-4)。PPP2R2A/PP2A，B55-α/PR55-α异构体通过特异性的WD-40重复序列(5)和1型TGF-β受体相互作用，有助于TGF-β受体抗增殖功能的发挥(6)。Application References |
| 存放说明 | -20C |
| 计算分子量 | 52 |
| 参考文献 | 1 . Li HH et al. (2007) EMBO J 26, 402–11 2 . Mayer-Jaekel, R.E. et al. (1993) Cell 72, 621-33. 3 . Clarke, P.R. et al. (1993) Mol Biol Cell 4, 397-411. 4 . Healy, A.M. et al. (1991) Mol Cell Biol 11, 5767-80. 5 . Neer, E.J. et al. (1994) Nature 371, 297-300. 6 . Griswold-Prenner, I. et al. (1998) Mol Cell Biol 18, 6595-604. 7 . Batut, J. et al. (2008) Development 135, 2927-37. |
Western blot analysis of extracts from various cell lines using PPP2R2A (2G9) Mouse mAb.Western blot方法检测不同细胞提取物，使用的抗体为PPP2R2A (2G9) Mouse mAb。 |
