| 货号 | 8462T |
| 同种亚型 | Rabbit IgG |
| 反应种属 | Human,Mouse,Rat,Monkey, |
| 来源宿主 | Rabbit IgG |
| 应用 | WB, IP |
| 目标/特异性 | CYLD (D1A10) Rabbit mAb recognizes endogenous levels of total CYLD protein. This antibody detects an unidentified protein of approximately 28 kDa in some cell types. |
| 使用方法 | WB(1:1000) IP (1:200) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | CYLD is a cytoplasmic deubiquitinating enzyme encoded by a tumor suppressor gene altered in individuals diagnosed with cylindromatosis, a genetic condition characterized by benign tumors of skin appendages (1,2). Functional CYLD deubiquitinase regulates inflammation and cell proliferation by down regulating NF-κB signaling through removal of ubiquitin chains from several NF-κB pathway proteins (3,4). CYLD is a negative regulator of proximal events in Wnt/β-catenin signaling and is a critical regulator of natural killer T cell development (5,6). The transcription factor Snail can inhibit CYLD expression, resulting in melanoma cell proliferation (7). |
| 存放说明 | -20C |
| 计算分子量 | 108 |
| 参考文献 | 1 . Biggs, P.J. et al. (1995) Nat Genet 11, 441-3. 2 . Sun, S.C. (2010) Cell Death Differ 17, 25-34. 3 . Regamey, A. et al. (2003) J Exp Med 198, 1959-64. 4 . Glittenberg, M. and Ligoxygakis, P. (2007) Fly (Austin) 1, 330-2. 5 . Tauriello, D.V. et al. (2010) Mol Cell 37, 607-19. 6 . Lee, A.J. et al. (2010) EMBO J 29, 1600-12. 7 . Massoumi, R. et al. (2009) J Exp Med 206, 221-32. |
Western blot analysis of extracts from various cell lines using CYLD (D1A10) Rabbit mAb. Western blot检测多种细胞提取物。 |
