| 货号 | 8576T |
| 同种亚型 | Rabbit IgG |
| 反应种属 | Human, |
| 来源宿主 | Rabbit IgG |
| 应用 | WB |
| 目标/特异性 | GOPC (D10A12) Rabbit mAb detects endogeneous levels of total GOPC protein. |
| 使用方法 | WB(1:1000) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | GOPC (FIG) was originally identified as a Golgi-associated, PDZ domain containing protein. It has two coiled-coil domains (CC1 and CC2) located in the amino-terminal region and a PDZ domain in the carboxy-terminal region (1). The CC2 domain and its adjacent linker region mediate the association of GOPC with the golgi protein golgin-160 and the Q-SNARE protein syntaxin 6 (1,2). The PDZ domain of GOPC interacts with the carboxy terminus of target proteins to mediate target protein vesicular trafficking and surface expression (3-6). Fusion of the corresponding GOPC gene with the ROS tyrosine kinase oncogene has been detected in some glioblastomas. The resulting GOPC-ROS fusion protein is targeted to the golgi apparatus where a constitutively activate ROS tyrosine kinase can mediate tumor formation (7,8). |
| 存放说明 | -20C |
| 计算分子量 | 59 |
| 参考文献 | 1 . Charest, A. et al. (2001) J Biol Chem 276, 29456-65. 2 . Hicks, S.W. and Machamer, C.E. (2005) J Biol Chem 280, 28944-51. 3 . Cheng, J. et al. (2002) J Biol Chem 277, 3520-9. 4 . He, J. et al. (2004) J Biol Chem 279, 50190-6. 5 . Wente, W. et al. (2005) J Biol Chem 280, 32419-25. 6 . Ito, H. et al. (2006) Biochem J 397, 389-98. 7 . Charest, A. et al. (2003) Proc Natl Acad Sci USA 100, 916-21. 8 . Charest, A. et al. (2006) Cancer Res 66, 7473-81. |
Western blot analysis of extracts from various cell lines using GOPC (D10A12) Rabbit mAb. 对多个细胞系使用GOPC (D10A12) Rabbit mAb兔单抗进行Western blot分析。 |
