Jak3 (D1H3) Rabbit mAb
货号：
8827T 基本售价：
1350.0 元 规格：
-
产品信息
概述| 货号 | 8827T |
| 同种亚型 | Rabbit IgG |
| 反应种属 | Human, |
| 来源宿主 | Rabbit IgG |
| 应用 | WB, IP , IF-IC |
| 目标/特异性 | Jak3 (D1H3) Rabbit mAb recognizes endogenous levels of total Jak3 protein. |
| 使用方法 | WB(1:1000)
IP (1:100)
IF-IC (1:200) |
性能| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | Members of the Janus family of tyrosine kinases (Jak1, Jak2, Jak3, and Tyk2) are activated by ligands binding to a number of associated cytokine receptors (1). Upon cytokine receptor activation, Jak proteins become autophosphorylated and phosphorylate their associated receptors to provide multiple binding sites for signaling proteins. These associated signaling proteins, such as Stats (2), Shc (3), insulin receptor substrates (4), and focal adhesion kinase (FAK) (5), typically contain SH2 or other phospho-tyrosine-binding domains. |
| 存放说明 | -20C |
| 计算分子量 | 115 |
| 参考文献 | 1 . Leonard, W.J. and OShea, J.J. (1998) Annu Rev Immunol 16, 293-322.
2 . Darnell, J.E. (1997) Science 277, 1630-5.
3 . VanderKuur, J. et al. (1995) J Biol Chem 270, 7587-93.
4 . Argetsinger, L.S. et al. (1995) J Biol Chem 270, 14685-92.
5 . Zhu, T. et al. (1998) J Biol Chem 273, 10682-9.
6 . Thomis, D.C. et al. (1995) Science 270, 794-7.
7 . Rikova, K. et al. (2007) Cell 131, 1190-203.
8 . Nosaka, T. et al. (1995) Science 270, 800-2.
9 . Park, S.Y. et al. (1995) Immunity 3, 771-82.
10 . Russell, S.M. et al. (1994) Science 266, 1042-5.
11 . Johnston, J.A. et al. (1994) Nature 370, 151-3.
12 . Oakes, S.A. et al. (1996) Immunity 5, 605-15.
13 . Zhou, Y.J. et al. (1997) Proc Natl Acad Sci USA 94, 13850-5.
14 . Cheng, H. et al. (2008) Mol Cell Biol 28, 2271-82.
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参考图片Confocal immunofluorescent analysis of KARPAS-299 cells (left) and A549 cells (right) using Jak3 (D1H3) Rabbit mAb (green). Blue pseudocolor = DRAQ5® #4084 (fluorescent DNA dye).共聚焦免疫荧光分析KARPAS-299 细胞 (左图) 和A549 细胞(右图)，所用抗体为Jak3 (D1H3) Rabbit mAb (绿色)。Blue pseudocolor = DRAQ5® #4084 (DNA荧光染料)。 |
