| 货号 | 5888T |
| 同种亚型 | Rabbit IgG |
| 反应种属 | Human, |
| 来源宿主 | Rabbit IgG |
| 应用 | WB |
| 目标/特异性 | LATS2 (D83D6) Rabbit mAb detects transfected levels of total LATS2 protein. |
| 使用方法 | WB(1:1000) |
| 供应商 | CST |
| 灵敏度 | Transfected Only |
| 背景 | LATS2 is an AGC kinase of the NDR family of kinases. It is a tumor suppressor of the LATS family, and plays a critical role in centrosome duplication, maintenance of mitotic fidelity, and genomic stability (1). LATS2 inhibits cell growth at the G1/S transition by down-regulating cyclin E/CDK2 kinase activity (2). It also plays an important role in regulation of the Hippo pathway, a pathway that is important in controlling organ size and tumor progression by regulating cellular proliferation and promoting apoptosis (3,4,5)LATS2是属于NDR激酶家族的一种AGC激酶。它是LATS家族的一种肿瘤抑制基因，在中心体复制、有丝分裂保真度维持和基因组稳定性中发挥重要作用(1)。LATS2通过下调周期蛋白E/CDK2激酶活性来抑制G1/S转化时的细胞生长(2)。它也可以调节Hippo通路，该通路能够调节细胞增殖和促进凋亡从而控制器官大小和肿瘤的进程(3,4,5)。 |
| 存放说明 | -20C |
| 计算分子量 | 150 |
| 参考文献 | 1 . Yabuta, N. et al. (2007) J Biol Chem 282, 19259-71. 2 . Li, Y. et al. (2003) Oncogene 22, 4398-405. 3 . Harvey, K. and Tapon, N. (2007) Nat Rev Cancer 7, 182-91. 4 . Zeng, Q. and Hong, W. (2008) Cancer Cell 13, 188-92. 5 . Visser, S. and Yang, X. (2010) Cell Cycle 9, 3892-903. |
Western blot analysis of extracts from HeLa cells, untransfected (-) or transfected with human LATS2 (+), using LATS2 (D83D6) Rabbit mAb.western blot方法检测未转染（-）和转染人类LATS2（+）的HeLa细胞提取物，使用的抗体为LATS2 (D83D6) Rabbit mAb。 |
