Bta-Catenin Alexa 488 14 100Tst
货号：
562505 基本售价：
5685.0 元 规格：
-
产品信息
概述| 货号 | 562505 |
| 描述 | The 14/Beta-Catenin monoclonal antibody specifically binds to Beta-Catenin ( β-Catenin).β -Catenin is a 92 kDa protein that binds to the cytoplasmic tail of E-Cadherin. The cadherins, transmembrane adhesion molecules, are found with catenins at adherens junctions (zonula adherens). Deletions in the cytoplasmic domain of E-Cadherin which eliminate catenin binding also result in a loss of cell adhesion, indicating that this binding is essential for E-Cadherin function. Although the α - and β -Catenins have been cloned, very little is known about their biochemical roles. However a link between β -Catenin and colon cancer has been described. β -Catenin was found to co-immunoprecipitate with the APC tumor suppressor protein in human colorectal tumor cell lines, as well as in human kidney 293 cells. E-Cadherin, however, was not detectable in these complexes. Thus the APC-Catenin complex may be affecting the transmission of contact inhibition signals and/or the regulation of cell adhesion. |
| 别名 | CTNNB1; CTNB1; Catenin beta-1; catenin (cadherin-associated protein) beta 1 |
| 同种亚型 | Mouse IgG1 |
| 反应种属 | Human (QC Testing) Mouse (Tested in Development) |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Mouse β-Catenin aa. 571-781 |
| 标记 | Alexa Fluor 488 |
| 存放说明 | Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.The antibody was conjugated to Alexa Fluor® 488 under optimum conditions, and unreacted Alexa Fluor® 488 was removed.
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| 存储溶液 | Aqueous buffered solution containing BSA, protein stabilizer, and ≤0.09% sodium azide. |
