Ms CTLA-4 IgG Fusion Protein NALE 500ug
货号：
552133 基本售价：
5040.0 元 规格：
-
产品信息
概述| 货号 | 552133 |
| 描述 | The Non-Cytolytic Mouse CTLA-4 - IgG Fusion Protein is composed of the extracellular domain of mouse CTLA-4 (CD152) fused to a mutant Fc region of mouse IgG2a, which is unable to bind to the C1q complement or to Fc receptors. This chimeric protein binds to CTLA-4s ligands B7-1 (CD80) and B7-2 (CD86) on mouse antigen-presenting cells and blocks their binding to both CTLA-4 and CD28. CTLA-4 (also known as CD152) is a cell-surface Ig-superfamily glycoprotein closely related to the CD28 costimulatory receptor. CTLA-4 is expressed on activated T lymphocytes 2-3 days after stimulation through the T-cell receptor. Whereas CD28 delivers a costimulatory signal required for T-cell activation, CTLA-4 is a negative regulator of cell-mediated immune responses. CTLA-4 IgG Fusion Protein has been shown to prevent allograft rejection and induce donor-specific tolerance, inhibit in vitro responses of splenocytes to ConA; inhibit the spontaneous in vitro and in vivo lymphoproliferation in CTLA-4-deficient mice; and limit superantigen-induced T-cell proliferation, anergy, and secretion of IL-2, IFN- γ , and IL-4, but not TNF- α or IL-10. |
性能| 供应商 | BD Pharmingen |
| 标记 | NA/LE |
| 存放说明 | This preparation contains no preservatives, thus it should be handled under aseptic conditions.The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.Avoid multiple freeze-thaws of product.
The fusion protein solution should be stored at -20°C until the vial is opened. Thawed aliquots may be stored for at least 1 week at 4°C. |
| 存储溶液 | No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2µm filtered. Endotoxin level is ≤0.01 ng/µg of protein. |
| 浓度 | 0.5 mg/ml |
