Rat CD28 NALE JJ316 500ug
货号：
554992 基本售价：
4956.0 元 规格：
-
产品信息
概述| 货号 | 554992 |
| 描述 | The JJ316 antibody reacts with CD28 on virtually all T lymphocytes bearing αβT-cell receptors (TCR), on most γδTCR-bearing T cells, and on a subset of NK cells. In the thymus, CD28 expression is developmentally regulated during the maturation of αβTCR-bearing T cells. CD28 is a costimulatory receptor required for activation of T cells; its ligands include CD80 (B7-1) and CD86 (B7-2). Soluble JJ316 enhances the proliferative responses and IL-2 production by T cells activated by anti-aß-TCR mAb R73 (Cat. no. 554910). Furthermore, at high concentrations, cross-linked JJ316 mAb stimulates resting CD4+ and CD8+T cells to proliferate, secrete IL-2, express activation markers, and gain CTL activity in the absence of signaling through the TCR. In vivo administration of mAb JJ316 results in blastogenic transformation of peripheral CD4+ cells and dramatic lymphocytosis. The alternate anti-rat CD28 mAb JJ319 (Cat. no. 554993) cannot directly activate T cells, although it has in vitro costimulatory activity. |
| 同种亚型 | IgG1,κ |
| 反应种属 | Rat (QC Testing) |
| 来源宿主 | Mouse |
| 使用方法 | FC, Cost, IP |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Rat Cd28-transfected BALB/c mouse A20J B lymphoma |
| 标记 | NA/LE |
| 存放说明 | Store undiluted at 4°C.The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.This preparation contains no preservatives, thus it should be handled under aseptic conditions.
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| 存储溶液 | No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2µm sterile filtered. Endotoxin level is ≤0.01 EU/µg (≤0.001 ng/µg) of protein as determined by the LAL assay. |
| 浓度 | 1.0 mg/ml |
