CD304 (BDCA-4/Neuropilin-1) MB Kit, h
货号：
130-090-532 基本售价：
询价 规格：
EA
产品信息
概述| 货号 | 130-090-532 |
| 描述 | The CD304 (BDCA-4/Neuropilin-1) MicroBead Kit has been developed for the enrichment of plasmacytoid dendritic cells (PDCs) from PBMCs by positive selection. |
性能| 供应商 | Miltenyi |
| 背景 | CD304 (BDCA-4/Neuropilin-1)1 is specifically expressed by PDCs in human blood1–5, bone marrow6, and cord blood11. Exclusive expression of CD304 (BDCA-4/Neuropilin-1) on PDCs allows their direct isolation. In blood and bone marrow, CD304 (BDCA-4/Neuropilin-1)+ PDCs are CD4+, CD45RA+, CD303 (BDCA-2)+, CD141 (BDCA-3)dim, CD1c (BDCA-1)–, and CD2–. They lack expression of lineage markers (CD3, CD14, CD16, CD19, CD20, CD56) and neither express myeloid markers such as CD13 and CD33, nor Fc receptors such as CD32, CD64, or FcεRI. Their lymphoid origin is indicated by their plasmacytoid morphology and the expression of the pre-T cell receptor α-chain. Freshly isolated CD1c (BDCA-1)+ or CD141 (BDCA-3)++ myeloid blood dendritic cells and monocytes do not express CD304 (BDCA-4/Neuropilin-1), but expression of CD304 (BDCA-4/Neuropilin-1) is induced on myeloid blood dendritic cells and monocytes upon culturing.1, 6 In inflamed tonsils, CD304 (BDCA-4/Neuropilin-1) expression is, apart from PDCs, also detected on some other cells, primarily follicular B helper memory T cells.6 |
