Plasma Cell Isolation Kit II, human
货号：
130-093-628 基本售价：
询价 规格：
EA
产品信息
概述| 货号 | 130-093-628 |
| 描述 | The Plasma Cell Isolation Kit II has been developed for the isolation of plasma cells from human PBMCs or bone marrow. |
性能| 供应商 | Miltenyi |
| 背景 | Human plasma cells are a heterogenous cell population comprising several subsets from short-lived and proliferative plasmablasts in lymphoid tissues, transitional plasma cells in peripheral blood to long-lived and non-dividing plasma cells in bone marrow1–3. Plasma cells of all differentiation stages are identified by the expression of high levels of the CD38 antigen. Other surface markers, however, are differentially regulated dependent on the stage of differentiation and the spatial localization. Plasma cells in the blood circulation lack the expression of the typical B cell marker CD22 and were found to express lower levels of CD19 than mature B cells.1 They are further characterized as being CD27++, CD31+, CD44+, CD45+, CD56–, CD62L+, CD86+, and HLA-DR+.1,4 A subset of CD38+ blood plasma cells further expresses the CD138 antigen, whereas all CD38+ plasma cells are also CD138+ in bone marrow.4 For the isolation of malignant plasma cells from bone marrow, the addition of CD56 MicroBeads may be left aside to avoid depletion of CD56-expressing tumor cells. |
