Phospho-CD79A (Tyr182) Antibody【科瑞奥博】

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Phospho-CD79A (Tyr182) Antibody

货号： 5173S 基本售价： 3980.0 元规格： 100ul

产品信息

概述
货号	5173S
反应种属	Human
来源宿主	Rabbit
应用	W/IP/IF-IC/F
目标/特异性	Phospho-CD79A (Tyr182) Antibody detects endogenous levels of CD79A protein only when phosphorylated on Tyr182 of CD79A.
使用方法	WB(1:1000) IP (1:50) F (1:100) IF-IC (1:200)

性能
供应商	CST
背景	Antigen receptors found on the surface of B-cells contain a hetrodimeric signaling component composed of CD79A and CD79B, also known as Ig α and Ig β, respectively (1,2). Presence of this receptor complex is essential for B-cell development and function (3). Together these two proteins and the associated B cell receptor initiate intracellular signaling following antigen binding (4,5). An immunoreceptor tyrosine-based activation motif (ITAM) is found in the CD79A intracellular region appears to be is important for its function (6). Antigen binding precedes formation of the CD79A and CD79B heterodimer and subsequent activation of receptor associated kinases (7). CD79A is a marker for B-lineage lymphoblastic leukemia (8); mutations in the corresponding mb-1 gene are responsible for abnormally low levels of functional B cell receptors in some cases of chronic B-cell lymphocytic leukemia (9).
存放说明	-20C
计算分子量	45-55

参考图片

Flow cytometric analysis of Ramos cells, untreated (blue) or IgM-treated (green), using Phospho-CD79A (Tyr182) Antibody.流式细胞仪分析未经处理的(蓝色)和经IgM处理的(绿色)Ramos细胞，所用抗体为Phospho-CD79A (Tyr182) Antibody。

Western blot analysis of extracts from Ramos cells untreated or treated with anti-human IgM (12 µg/ml for 10 minutes), using Phospho-CD79A (Tyr182) Antibody (upper) or CD79A Antibody #3351 (lower).Western免疫印迹。用 Phospho-CD79A (Tyr182) Antibody (上图) 或 CD79A Antibody #3351 (下图)研究未经处理的和经anti-human IgM (12 µg/ml，10 min)处理的Ramos细胞的细胞提取液。

Confocal immunofluorescent analysis of Ramos cells, untreated (left) or IgM-treated (middle), and Jurkat cells (right) using Phospho-CD79A (Tyr182) Antibody (green). Blue pseudocolor = DRAQ5® #4084 (fluorescent DNA dye).共聚焦免疫荧光分析Ramos细胞，未经处理 (左图)，经IgM处理的(中间图)和Jurkat细胞(右图)，所用抗体为Phospho-CD79A (Tyr182) Antibody(绿色)。Blue pseudocolor = DRAQ5® #4084 (DNA荧光染料)。