| 货号 | FAB5899R-100UG |
| 别名 | cadherin-like 1; Cadherin-like protein 1; FLJ53887; MGC45991; PC42; PC42PCDH42; PCDH1; PCDH42; protocadherin 1 (cadherin-like 1); protocadherin 1; protocadherin 42; Protocadherin1; Protocadherin-1; Protocadherin-42 |
| 应用 | Flow Cytometry |
| 目标/特异性 | Detects human Protocadherin-1 in direct ELISAs. |
| 使用方法 | Flow Cytometry: 0.25-1 µg/106cells |
| 来源 | The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below. |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 5097 (Human); 75599 (Mouse); 307481 (Rat) |
| 免疫原 | E. coli-derived recombinant human Protocadherin-1 Thr58-Asn162 Accession # Q08174 |
| 生物活性 | Human |
| 标记 | Alexa Fluor 647 |
| 背景 | Protocadherin-1 (PCDH-1; also PC42) is a 150 - 170 kDa δ1 subgroup member of the nonclustered protocadherin family of molecules. It is expressed on macrophages, respiratory epithelium, endothelial cells and neurons. Protocadherin-1 apparently forms homophilic Ca++-dependent complexes and likely serves as an adhesion molecule. Human full-length Protocadherin-1 precursor is 1237 amino acids (aa) in length. It is a type I transmembrane glycoprotein that contains a 795 aa extracellular domain (ECD) (aa 58-852) plus a 364 aa cytoplasmic region. There are seven cadherin domains in the ECD (aa 58-844), and an RRVTF cytoplasmic motif that binds PP1 alpha phosphatase. There are multiple splice variants. Alternative start sites exist at Met23 and Met235, there is a deletion of aa 209-220, and a 27 aa substitution for aa 1034-1237. Over aa 58-162, human Protocadherin-1 shares 96% aa identity with mouse Protocadherin-1. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 参考文献 |
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