Human Coagulation Factor III/Tissue Factor A647 Antibody (100 UG)【科瑞奥博】

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Human Coagulation Factor III/Tissue Factor A647 Antibody (100 UG)

货号： FAB23391R-100UG 基本售价： 4659.8 元规格： 100 UG

产品信息

概述
货号	FAB23391R-100UG
别名	CD142 antigen; CD142; coagulation factor III (thromboplastin, tissue factor); Coagulation Factor III; F3; FLJ17960; TF; TFA; Thromboplastin; Tissue Factor
应用	Flow Cytometry
目标/特异性	Detects human Coagulation Factor III/Tissue Factor in direct ELISAs and Western blots. In direct ELISAs and Western blots, no cross-reactivity with recombinant mouse Coagulation Factor III/Tissue Factor is observed.
使用方法	Flow Cytometry: 0.25-1 µg/10⁶cells
来源	The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
产品组分

性能
供应商	R&D Systems
Entrez Gene IDs	2152 (Human); 14066 (Mouse)
纯化方式	Protein A or G purified from hybridoma culture supernatant
免疫原	Mouse myeloma cell line NS0-derived recombinant human Coagulation Factor III Gly34-Glu251 Accession # P13726
生物活性	Human
标记	Alexa Fluor 647
背景	Coagulation Factor III/Tissue Factor (TF), also known as thromboplastin and CD142, is a type I transmembrane protein found in a variety of cell types. It functions as a protein cofactor/receptor of Coagulation Factor VII, which is synthesized in the liver and circulated in the plasma (1). Upon binding of TF, the inactive factor VII is rapidly converted into activated VIIa. The resulting 1:1 complex of VIIa and TF initiates the coagulation pathway and has also important coagulation-independent functions such as angiogenesis (2). TF is synthesized as a 295 amino acid (aa) precursor, with a signal peptide (aa 1-32), an extracellular domain (aa 33-251), a transmembrane region (aa 252-274) and a cytoplasmic tail (aa 275-295) (3‑6).
运输条件	Blue Ice
存放说明	4℃
参考文献	Morrissey, J.H. (2004) in Handbook of Proteolytic Enzymes. Barrett, A.J. et al. (ed) San Diego, Academic Press, p. 1659. Versteeg, H.H. et al. (2003) Carcinogenesis 24:1009. Scarpati, E.M. et al. (1987) Biochemistry 26:5234. Fisher, K.L. et al. (1987) Thromb. Res. 48:89. Morrissey, J.H. et al. (1987) Cell 50:129. Spicer, E.K. (1987) Proc. Natl. Acad. Sci. USA 84:5148.

参考图片

Detection of Coagulation Factor III/Tissue Factor in Human PBMCs by Flow Cytometry Human peripheral blood mononuclear cells (PBMCs) were stained with Mouse Anti-Human CD14 PE‑conjugated Monoclonal Antibody (Catalog # FAB3832P) and either (A) Mouse Anti-Human Coagulation Factor III/Tissue Factor Alexa Fluor® 647‑conjugated Monoclonal Antibody (Catalog # FAB23391R) or (B) Mouse IgG1 Alexa Fluor 647 Isotype Control (Catalog # IC002R). View our protocol for Staining Membrane-associated Proteins.