CD262-Biotin, human
货号：
130-097-303 基本售价：
询价 规格：
EA
产品信息
概述| 货号 | 130-097-303 |
| 描述 | The DJR2-4 antibody binds to Death Receptor 5 (DR5), member 10B of the TNF receptor superfamily (TNFRSF10B), also known as CD262, TRAIL-R2/ TRAILR2, TRICK2, KILLER, and ZTNFR9. Binding of “TNF-related apoptosis-inducing ligand” (TRAIL, TNFSF10, TL2, APO2L, Apo-2L) to DR5 induces apoptosis via the intracellular adaptor molecule FADD/MORT. The DR5 receptor is broadly expressed on many tumors and normal tissues. DR5 expression is upregulated by interferon-alpha, taxotere and paclitaxel, making DR5+ target cells more susceptible to NK cell mediated killing. |
| 别名 | TNFRSF10B, DR5, KILLER, TRAIL-R2, TRICK2, TRICK2A, TRICK2B, TRICKB, ZTNFR9 |
| 克隆号 | DJR2-4 |
| 同种亚型 | mouse IgG1κ |
