Anti-HLA-E-Biotin, human
货号：
130-096-890 基本售价：
询价 规格：
EA
产品信息
概述| 货号 | 130-096-890 |
| 描述 | The 3D12 monoclonal antibody recognizes the human HLA-E protein, a member of the human leukocyte antigen family. HLA-E is a non-classical MHC molecule (MHC-Ib) with limited polymorphisms, which is expressed on the cell surface in a heterodimeric complex with β2-microglobulin. HLA-E is ubiquitously expressed and has a specialized role in NK cell recognition. It binds a restricted set of peptides, e.g., derived from other class I leader sequences. The complex is recognized by NKG2A on NK cells. This recognition protects the HLA-E–expressing cell from NK cell killing. Recently HLA-E recognition by a specialised subset of CD8 T cells has been implicated in pathogen recognition as well as autoimmunity. 1, 2, 3 |
| 别名 | QA1, EA1.2, EA2.1, HLA-6.2, MHC, HLA-E |
| 克隆号 | 3D12 |
| 同种亚型 | mouse IgG1κ |
