CD85j (ILT2)-PE-Vio770, human 30 tests
货号：
130-101-551 基本售价：
询价 规格：
30 tests
产品信息
概述| 货号 | 130-101-551 |
| 描述 | Clone GHI/75 reacts with CD85j (ILT2), an inhibitory immunoreceptor of the immunoglobulin-like transcript (ILT) family. CD85j is a type I transmembrane protein with four extracellular Ig-like domains and four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs) in its cytoplasmic tail. The inhibitory signal is transmitted by recruiting SH2-containing protein tyrosine phosphatase-1 that dephosphorylates and inactivates downstream tyrosine kinases. Expression of CD85j is found on B cells, monocytes, dendritic cells, and subsets of natural killer (NK) and T cells. CD85j is known to bind classical and non-classical MHC class I molecules, human cytomegalovirus UL18 protein, and some HLA-C alleles, as ligands. Crosslinking of CD85j prevents activation of B cells, T cells, NK cells, macrophages, and downregulation of effector mechanisms, such as NK and T cells cytolytic functions. |
| 别名 | LILRB1, ILT2, LIR-1, MIR-7 |
| 克隆号 | GHI/75 |
| 同种亚型 | mouse IgG2bκ |
