Anti-CX3CR1-APC, human & nhp 30 tests
货号：
130-105-897 基本售价：
询价 规格：
30 tests
产品信息
概述| 货号 | 130-105-897 |
| 描述 | Clone REA385 recognizes the human CX3C chemokine receptor 1 antigen, a 40 kDa G-protein-coupled multi-pass membrane protein also known as fractalkine receptor. CX3CR1 is expressed on NK cells, T cell subsets, monocytes/macrophages, dendritic cells, and some malignant epithelial cells. Binding of CX3CR1 to the membrane-bound form of the chemokine CX3CL1 promotes cell-cell adhesion, whereas the soluble form induces cell migration of CX3CR1-bearing cells such as monocytes, NK cells, T cells, dendritic cells (DCs), and macrophages including microglia. CX3CR1 plays also an important role in the formation of transepithelial dendrites by intestinal DCs. Failure in the CX3CL1/CX3CR1 interaction may contribute to the development of several inflammatory diseases including atherosclerosis, psoriasis, rheumatoid arthritis, and experimental autoimmune myositis. Additional information: Clone REA385 displays negligible binding to Fc receptors. |
| 别名 | CCRL1, CMKBRL1, CMKDR1, GPR13, GPRV28, V28, GPRV28, RBS11 |
| 克隆号 | REA385 |
| 同种亚型 | recombinant human IgG1 |
