CD184 (CXCR4)-PE, human
货号：
130-109-885 基本售价：
询价 规格：
EA
产品信息
概述| 货号 | 130-109-885 |
| 描述 | Clone REA649 recognizes the human CD184 antigen, a multi-pass membrane protein, also known as C-X-C chemokine receptor type 4 (CXCR4), leukocyte-derived seven transmembrane domain receptor (LESTR), or fusin. CD184 is ubiquitously expressed on blood and tissue cells. It mediates chemotaxis in mature and progenitor blood cells and is important for B lympho- and myelopoiesis and cardiogenesis. CD184 exclusively interacts with the endogenous ligand CXCL12. Binding of CXCL12 transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Although CXCL12 is the only known chemokine that binds CD184, recent studies suggest that extracellular ubiquitin also acts as an immune modulator through CD184-mediated signaling. CD184 is a co-receptor for HIV entry by promoting Env-mediated fusion of the virus.Additional information: Clone REA649 displays negligible binding to Fc receptors. |
| 别名 | CXCR4, Fusin, LESTR, FB22, HM89, LCR1, LAP-3, NPYRL |
| 克隆号 | REA649 |
| 同种亚型 | recombinant human IgG1 |
