CD87-PE, human 30 tests
货号：
130-099-458 基本售价：
询价 规格：
30 tests
产品信息
概述| 货号 | 130-099-458 |
| 描述 | Clone VIM5 recognizes CD87, a 36-38 kDa GPI-anchored cell-surface receptor. CD87, also known uPAR, binds uPA and thus facilitating the catalytic C domain of the uPA to come in close proximity of membrane bound plasminogen. uPA is a serine protease, which converts plasminogen into plasmin which in-turn is involved in digestion of various extracellular matrix proteins. CD87 belongs to the Ly6/neurotoxin receptor family and consists of three disulfide-bonded homologous domains, D1, D2 and D3. Function of uPAR is modulated by two inhibitors, PA1 and PA2. The expression of membrane-bound CD87 is found on granulocytes, monocytes/macrophages, dendritic cells, fibroblasts, endothelial cells and keratinocytes. Multiple known regulatory functions of CD87 include cell migration, leukocyte adhesion, chemotaxis, signal transduction and tissue remodeling. |
| 别名 | PLAUR, U-PAR, URKR |
| 克隆号 | VIM5 |
| 同种亚型 | mouse IgG1κ |
