CD79b-PE, human 30 tests
货号：
130-099-106 基本售价：
询价 规格：
30 tests
产品信息
概述| 货号 | 130-099-106 |
| 描述 | Clone REA120 detects the extracellular epitope of CD79b, the β chain of heterodimeric molecule CD79. CD79 is composed of α chain (CD79a) and β chain (CD79b) and is associated with surface immunoglobulins (Igs) to form the B cell receptor (BCR). CD79b is 37–39 kDa type I integral membrane protein and like CD79a contains an intracellular immunoreceptor tyrosine-based activation motif (ITAM). CD79a/CD79b heterodimer facilitates differentiation of pre–B cells from pro–B cells, surface expression of sIg, signal transduction following antigen recognition, and enodocytosis of recognised antigens. Patients with chronic lymphocytic leukemia (CLL) B cells lack a functional BCR which is often associated with mutations in CD79b coding region.Additional information: Clone REA120 displays negligible binding to Fc receptors. |
| 别名 | AGM6, B29, Igb |
| 克隆号 | REA120 |
| 同种亚型 | recombinant human IgG1 |
