CD41a-PE human 30 tests
货号：
130-105-612 基本售价：
询价 规格：
30 tests
产品信息
概述| 货号 | 130-105-612 |
| 描述 | Clone REA386 recognizes the human CD41a antigen, a calcium-dependent complex of CD41/CD61 (GPIIb/IIIa) expressed on normal platelets and megakaryocytes. The CD41/CD61 complex is a receptor for fibronectin, fibrinogen, von Willebrand factor, vitronectin, and thrombospondin and is required for platelet aggregation and clotting. Mutations of either CD41 or CD61 in humans causes Glanzmann’s thrombasthenia. Notably, CD41 is also the first blood-specific marker during in vitro differentiation of embryonic stem cells and is expressed on all hematopoietic stem and progenitor cells in the early embryo. However, CD41 expression is downregulated in midgestation embryos, and it is currently thought that CD41 expression on adult hematopoietic stem cells remains switched off throughout adult life. Additional information: Clone REA386 displays negligible binding to Fc receptors. |
| 别名 | ITGA2B, BDPLT16, BDPLT2, GP2B, GPIIb |
| 克隆号 | REA386 |
| 同种亚型 | recombinant human IgG1 |
