CD352 (NTB-A)-PE, human 30 tests
货号：
130-105-594 基本售价：
询价 规格：
30 tests
产品信息
概述| 货号 | 130-105-594 |
| 描述 | Clone REA339 recognizes the human CD352 antigen, a 60 kD single-pass type I membrane protein also known as SLAM family member 6 (SLAM6) or NK-, T-, and B-cell antigen (NTB-A). CD352 belongs to the CD2 subfamily of the immunoglobulin superfamily and is expressed on NK, T, and B cells. It undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases. Monoclonal antibody-mediated cross-linking of CD352 results in the induction of NK-mediated cytotoxicity. CD352 also triggers cytolytic activity only in NK cells expressing high surface densities of natural cytotoxicity receptors. This suggests that CD352 may function as a coreceptor in the process of NK cell activation. Importantly, analysis of NK cells derived from patients with X-linked lymphoproliferative disease showed that the lack of SH2D1A protein profoundly affects the function of CD352. Additional information: Clone REA339 displays negligible binding to Fc receptors. |
| 别名 | SLAMF6, KALI, KALIb, LY108, NTB-A, NTBA, SF2000, SLAM6, TCOM |
| 克隆号 | REA339 |
| 同种亚型 | recombinant human IgG1 |
