CD344 (Frizzled-4)-PE, human 30 tests
货号：
130-106-613 基本售价：
询价 规格：
30 tests
产品信息
概述| 货号 | 130-106-613 |
| 描述 | Clone CH3A4A7 recognizes an extracellular epitope of the human CD344 antigen, a multi-pass membrane protein which is also known as Frizzled family receptor 4 (FZD4) or Frizzled-4. CD344 is expressed by neuronal stem cells and also found on fetal neuronal progenitor cells and neuronal intestinal cells. It is a member of the Frizzled family of proteins which encode seven-transmembrane domain proteins that are receptors for the wingless-type MMTV integration site family of signaling proteins. CD344 is involved in the activation of Wnt/β-catenin pathway (canonic Wnt signaling). It is the only representative of frizzled family members that binds strongly an additional ligand norrin that is functionally similar but structurally different from wingless-type proteins. CD344 signaling induced by norrin regulates vascular development of vertebrate retina and controls important blood vessels in the ear. |
| 别名 | FZD4, EVR1, FEVR, FZD4S, Fz-4, Fz4, FzE4, GPCR, hFz4 |
| 克隆号 | CH3A4A7 |
| 同种亚型 | mouse IgG1κ |
