CD307e (FCRL5)-PE, human 30 tests
货号：
130-106-044 基本售价：
询价 规格：
30 tests
产品信息
概述| 货号 | 130-106-044 |
| 描述 | Clone REA391 recognizes the human CD307e antigen, a 106 kD single-pass type I membrane protein also known as Fc receptor-like protein 5 (FcRL5) or immune receptor translocation-associated protein 2 (IRTA2). CD307e possesses a cytoplasmic tail with inhibitory ITIM phosphorylation signaling motifs. CD307e was found to inhibit B cell antigen receptor signaling by recruiting SHP1 to two ITIM motifs upon B cell antigen receptor co-stimulation, resulting in diminished calcium influx and protein tyrosine phosphorylation. Co-stimulation of CD307e and the B cell antigen receptor promotes proliferation and differentiation of naive B cells. CD307e is expressed on both mature B cells and plasma cells, and is induced by EBV proteins. It is overexpressed on malignant B cells of hairy cell leukemia, chronic lymphocytic leukemia, mantle cell lymphoma, and multiple myeloma patients. In addition, serum levels of soluble CD307e are elevated in patients with several types of B cell tumors. Additional information: Clone REA391 displays negligible binding to Fc receptors. |
| 别名 | FCRL5, BXMAS1, CD307, FCRH5, IRTA2, PRO820 |
| 克隆号 | REA391 |
| 同种亚型 | recombinant human IgG1 |
