CD159c (NKG2C)-PE, human 30 tests
货号：
130-103-700 基本售价：
询价 规格：
30 tests
产品信息
概述| 货号 | 130-103-700 |
| 描述 | Clone REA205 recognizes the CD159c antigen, a calcium-dependent (C-type) lectin, which is also known as NKG2C type II integral membrane protein or KLRC2. CD159c heterodimerizes with CD94 to form a complex that recognizes HLA-E as ligand. Clone REA205 detects the human CD159c/CD94 heterodimer and does not cross-react with the human CD159a/CD94 heterodimer or with the human CD94 homodimer. CD159c is expressed primarily on natural killer (NK) cells and receptor ligation results in NK cell activation. The proportion of CD3+ T cells expressing the CD159c/CD94 complex is elevated under pathologic conditions, such as human CMV infection, active celiac disease, paroxysmal nocturnal hemoglobinuria, Stevens-Johnson syndrome, and toxic epidermal necrolysis. Moreover, CD159c can mediate the expansion of infiltrating cytotoxic CD8+ T cells in active celiac patients. Additional information: Clone REA205 displays negligible binding to Fc receptors. |
| 别名 | KLRC2, CD159c, NKG2-C, NKG2C, KLRC2 |
| 克隆号 | REA205 |
| 同种亚型 | recombinant human IgG1 |
