Anti-LT-bR-PE, human 30 tests
货号：
130-106-748 基本售价：
询价 规格：
30 tests
产品信息
概述| 货号 | 130-106-748 |
| 描述 | Clone REA412 recognizes the human lymphotoxin beta receptor (LT-ßR) antigen, a 47 kDa single-pass type I membrane protein which is also known as tumor necrosis factor receptor superfamily member 3 (TNF-RIII). LT-ßR is a member of the TNF receptor family that play a role in the development and organization of lymphoid tissues. Unlike the other TNF receptors, LT-ßR does not bind a soluble ligand, but rather, a membrane form of a heterotrimeric lymphotoxin complex comprised of one LTα and two LTβ molecules. The development of lymph nodes is a process that involves the LT-ßR dependent crosstalk between mesenchymal lymphoid tissue organizer and hematopoietic lymphoid tissue inducer cells. Cell death induced by LT-ßR is dependent on TRAF3, whereas NFκB activation appears to be mediated by TRAF5 or TRAF2. LT-ßR is expressed on a variety of human primary and transformed cells, but is absent on T or B lymphocytes and primary monocytes or peripheral dendritic cells, although LT-ßR is detected on some myeloid leukemic lines. In the developing thymus LT-ßR is prominent along the trabeculae and into the medulla up to corticomedullary junction. In the spleen, LT-ßR is prominently expressed by cells in the red pulp and along the borders of red and white pulp which colocalizes with reticular stromal cells. Additional information: Clone REA412 displays negligible binding to Fc receptors. |
| 别名 | TNF-RIII, LTBR, D12S370, LT-BETA-R, TNF-RII, CD18, TNFR-RP, TNFR2-RP, TNFR3, TNFCR |
| 克隆号 | REA412 |
| 同种亚型 | recombinant human IgG1 |
