Anti-IL-12R B2-PE, human 30 tests
货号：
130-105-035 基本售价：
询价 规格：
30 tests
产品信息
概述| 货号 | 130-105-035 |
| 描述 | Clone REA333 recognizes the human interleukin-12 receptor subunit β-2 (IL-12R β2) antigen, a single-pass type I membrane protein which forms the functional high affinity IL-12 receptor together with the IL-12R β1 subunit. While the IL-12R β1 subunit is constitutively expressed, the expression of the IL-12R β2 gene is up-regulated by interferon γ. IL-12R β2 is expressed by Tʜ1 cells and IL-12 signaling through the IL-12 receptor leads to the phosphorylation of STAT4 and continued Tʜ1 differentiation. The IL-12R β2 subunit plays an important role in Tʜ1 cell differentiation, since its absence leads to an abortive Tʜ1 differentiation that has dysfunctional production of Tʜ1 effector molecules. The up-regulation of IL-12R β2 is found to be associated with a number of infectious diseases, such as Crohns disease and leprosy, which is thought to contribute to the inflammatory response and host defense. Additional information: Clone REA333 displays negligible binding to Fc receptors. |
| 别名 | IL12RB2 |
| 克隆号 | REA333 |
| 同种亚型 | recombinant human IgG1 |
