Anti-HLA-B7, B27-PE human 30 tests
货号：
130-106-047 基本售价：
询价 规格：
30 tests
产品信息
概述| 货号 | 130-106-047 |
| 描述 | Clone REA176 recognizes HLA B7 and B27, class I human leukocyte antigens (HLA). Expressed on the surface of most nucleated cells, class I molecules are heterodimeric molecules and consist of a type I integral membrane α heavy chain and soluble β2 microglobulin protein. The extracellular region of the heavy chain further consists of 3 domains, one of which comprises the peptide binding groove. Antigens binding to class I molecules are 8-10 amino acids long and play an important role in recognition of the virus infected and malignant cells by cytotoxic T lymphocytes (CTLs). In addition, class I molecules interact with NK cell receptors to modulate the activity of NK cells. HLA-B7 is a risk factor for cervical cancer, sarcoidosis, and early-onset spondylarthropathies. HLA-B27 is known for its strong association with inflammatory spondyloarthropathies. It has been also discovered as a protective factor against some severe viral infections.Additional information: Clone REA176 displays negligible binding to Fc receptors. |
| 别名 | HLA-B, AS, SPDA1 |
| 克隆号 | REA176 |
| 同种亚型 | recombinant human IgG1 |
