Anti-c-Cbl (PY774)-PE, human 30 tests
货号：
130-099-298 基本售价：
询价 规格：
30 tests
产品信息
概述| 货号 | 130-099-298 |
| 描述 | Clone REA118 recognizes the Y774-phosphorylated form of human c-Cbl, which is a member of Cbl family of proteins. Cbl proteins serve as the negative regulators of antigen receptor signaling and contain N-terminal tyrosine kinase-binding (TKB) domain, which mediates binding to specific phosphotyrosine motifs on activated protein tyosine kinases (PTKs), a Zn-coordinating RING finger domain that interacts with ubiquitin-conjugating enzymes (E2s), a proline-rich region and a C-terminal leucine zipper-like region. c-Cbl unlike the other cbl proteins contains only a short proline-rich region and no C-terminal leucine zipper-like region. Cbl proteins acts as E3 ubiquitin ligase and tranfer ubiquitin molecules to tag activated receptors, PTKS, and signaling molecules for degradation. Additional information: Clone REA118 displays negligible binding to Fc receptors. |
| 别名 | CBL, CBL2, FRA11B, NSLL, RNF55 |
| 克隆号 | REA118 |
| 同种亚型 | recombinant human IgG1 |
