Anti-Btk-PE, human 30 tests
货号：
130-105-598 基本售价：
询价 规格：
30 tests
产品信息
概述| 货号 | 130-105-598 |
| 描述 | Clone REA367 recognizes the human Btk (bruton tyrosine kinase) antigen, a non-receptor tyrosine kinase belonging to the Tec family of kinases. Btk is critical for B cell–development, –differentiation, and –signaling. Moreover, Btk expression is assumed to be a prerequisite for B cell–proliferation and survival. Consequently, Btk-deficient B lymphocytes fail to reach the mature state and are presumably doomed to premature death. Btk is reported to be associated with human disease. Thus, individuals harboring loss-of-function mutations in the gene encoding Btk virtually lack circulating B lymphocytes, are unable to generate immunoglobulins of all classes, and therefore cannot mount humoral immune responses. This primary immunodeficiency is named X-linked agammaglobulinemia. Additional information: Clone REA367 displays negligible binding to Fc receptors. |
| 别名 | AGMX1, AT, ATK, BPK, IMD1, PSCTK1, XLA |
| 克隆号 | REA367 |
| 同种亚型 | recombinant human IgG1 |
