Anti-ERK2-PE, human 30 tests
货号：
130-101-203 基本售价：
询价 规格：
30 tests
产品信息
概述| 货号 | 130-101-203 |
| 描述 | Clone REA186 recognizes ERK2, a 42 KDa serine/threonine protein kinase, which participates in the MAPK signal transduction pathway. It is involved in regulation of a large variety of processes including cell adhesion, cell cycle progression, cell migration, cell survival, differentiation, metabolism, proliferation, and transcription. ERK2 and the related kinase ERK1 are phosphorylated by kinases MEK1/2, leading to activation and nuclear translocation of ERKs, where they phosphorylate downstream targets, such as transcription factors including Ets, Elk, and c-Fos. ERK2 activation and mobilization is induced in reponse to several extracellular signals and engagement of receptors such as Tyr kinases (RTKs), G protein–coupled receptors (GPCRs), ion channels, and others. The ERK1/2 are dual specificity kinases and phosphorylate Ser or Thr residues neighbor to Proline residue.Additional Information: Clone REA186 displays negligible binding to Fc receptors. |
| 别名 | MAPK1, ERK, ERK-2, , ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38 |
| 克隆号 | REA186 |
| 同种亚型 | recombinant human IgG1 |
