CD146-Biotin, human, REA773, 30 tests
货号：
130-111-507 基本售价：
询价 规格：
30 tests
产品信息
概述| 货号 | 130-111-507 |
| 描述 | Clone REA773 recognizes the human CD146 antigen, also known as MUC18, MCAM, Mel-CAM, or S-Endo-1. CD146 is a transmembrane glycoprotein belonging to the immunoglobulin superfamily and contains five extracellular immunoglobulin (Ig)-like domains. CD146 possesses a limited tissue expression distribution, including endothelial cells, pericytes, smooth muscle cells, follicular dendritic cells, melanoma cells, and a sub-population of activated T lymphocytes. CD146 is also expressed on marrow stromal cells (MSCs). CD146 functions as a Ca2+-independent cell adhesion molecule that is involved in heterophilic cell-cell interactions, and may be involved in the extravasion and/or homing of activated T cells. CD146 expression in melanoma is also directly associated with tumor growth and metastasis.Additional information: Clone REA773 displays negligible binding to Fc receptors. |
| 别名 | MCAM, MUC18, Endo-CAM, Mel-CAM, S-endo |
| 克隆号 | REA773 |
| 同种亚型 | recombinant human IgG1 |
